Medical Biochemistry – part II

Content 1. Molecular diseases ……………………………………………………………………………………….. 2 2. Post-translational regulation of proteins ………………………………………………………… 6 3. Intercellular interactions and signal transduction …………………………………………… 12 4. Types of plasma membrane receptors ……………………………………………………………. 14 5. Participation of secondary mediators in signal transduction ……………………………. 25 6. Hormones ………………………………………………………………………………………………….. 35 6.1 Pituitary hormones ……………………………………………………………………………………. 37 6.1.1 Hormones from the anterior pituitary gland ……………………………………………… 38 6.1.2 Neurohypophysis Hormones (Posterior Pituitary) …………………………………….. 52 7. Hormones regulating water-salt metabolism …………………………………………………. 55 8. Pancreatic hormones ………………………………………………………………………………….. 59 9. Catecholamines ………………………………………………………………………………………….. 64 10. Gastrointestinal hormones …………………………………………………………………………. 66 11. Hormones with intracellular receptors ………………………………………………………… 68 12. Apoptosis …………………………………………………………………………………………………. 78 13. Mechanisms of oncogenesis ……………………………………………………………………….. 85 14. Pathobiochemical mechanisms of diabetes mellitus ……………………………………… 94 15. Biochemistry of blood …………………………………………………………………………………104 16. Mechanisms of cell adhesion ……………………………………………………………………… 131 17. Extracellular matrix (ECM) ………………………………………………………………………… 142 18. Bones as mineralized connective tissue ……………………………………………………….. 150 18.1 Biochemistry of cartilage ………………………………………………………………………….. 155 18.2 Calcium metabolism ………………………………………………………………………………… 157 18.3 Hormones affecting calcium metabolism …………………………………………………… 158 18.4 Biochemistry of teeth ………………………………………………………………………………. 160 19. Biochemistry of nutrition ……………………………………………………………………………164 20. Biochemistry of the liver. Metabolic functions. Synthesis of specific products. Biotransformation of xenobiotics …………………………………………………………………………. 184 Bibliography ………………………………………………………………………………………………….. 191…